Induction of cell-membrane porosity by ultrasound

K Tachibana, T Uchida, K Ogawa, N Yamashita… - The Lancet, 1999 - thelancet.com
within cells with acoustic energy. The cell-killing mechanism of these treatments has not
been clearly determined. To identify the site and degree of damage to tumour cells by …

Ultrasound Enhanced Drug Toxicity on Chinese Hamster Ovary Cells in Vitro

AH Saad, GM Hahn - Cancer research, 1989 - AACR
Chinese hamster ovary cells (HA1) were exposed to therapeutic ultrasound (F= 2.025 MHz)
in the presence of various drugs at temperatures of 37–43° C. The space averaged …

Plasma membrane poration induced by ultrasound exposure: implication for drug delivery

S Mehier-Humbert, T Bettinger, F Yan… - Journal of controlled …, 2005 - Elsevier
Sonoporation, in the presence of ultrasound contrast agents (UCA), is a technique that
permits the transfer of drugs, including genes, into cells. In this study, the size of the pores …

Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability

HR Guzman, DX Nguyen, S Khan… - The Journal of the …, 2001 - pubs.aip.org
Ultrasound-mediated drug delivery is a nonchemical, nonviral, and noninvasive method for
targeted transport of drugs and genes into cells. Molecules can be delivered into cells when …

Ultrasound-mediated disruption of cell membranes. II. Heterogeneous effects on cells

HR Guzman, DX Nguyen, S Khan… - The Journal of the …, 2001 - pubs.aip.org
Ultrasound has been shown to reversibly and irreversibly disrupt membranes of viable cells
through a mechanism believed to involve cavitation. Because cavitation is both temporally …

Distinct sensitivity of normal and malignant cells to ultrasound in vitro.

F Lejbkowicz, S Salzberg - Environmental health perspectives, 1997 - ehp.niehs.nih.gov
The effect of ultrasonic irradiation on the viability of human normal (foreskin fibroblast and
amniotic fluid epithelial) and tumor (breast carcinoma, melanoma, and lung carcinoma) cells …

[HTML][HTML] Sonodynamic therapy––a review of the synergistic effects of drugs and ultrasound

I Rosenthal, JZ Sostaric, P Riesz - Ultrasonics sonochemistry, 2004 - Elsevier
Sonodynamic therapy, the ultrasound dependent enhancement of cytotoxic activities of
certain compounds (sonosensitizers) in studies with cells in vitro and in tumor bearing …

The role of cavitation in the in vitro stimulation of protein synthesis in human fibroblasts by ultrasound

DF Webster, JB Pond, M Dyson, W Harvey - Ultrasound in medicine & …, 1978 - Elsevier
The synthesis of protein by human embryonic fibroblasts in vitro was stimulated by
irradiation with ultrasound at a frequency of 3 MHz, a spatial and temporal peak intensity of …

Potentiation of chemotherapy by low-level ultrasound

GH Harrison, EK Balcer-Kubiczek… - International journal of …, 1991 - Taylor & Francis
We have performed in vitro and in vivo tests to determine whether ultrasound (US) at levels
lower than previously investigated by others could still potentiate chemotherapeutic cell …

Ultrasound-induced cell lysis and sonoporation enhanced by contrast agents

M Ward, J Wu, JF Chiu - The Journal of the Acoustical Society of …, 1999 - pubs.aip.org
The enhancement of ultrasound-induced cell destruction, lysis, and sonoporation in low cell
concentration suspensions (2× 10 5/mL) by the presence of contrast agents (gas bubble to …