Stress has been shown to enhance pain sensitivity resulting in stress-induced hyperalgesia.
However, the underlying mechanisms have yet to be elucidated. Using single-prolonged …

The high comorbidity rates of posttraumatic stress disorder and chronic pain have been
widely reported, but the underlying mechanisms remain unclear. Emerging evidence …

Protein tyrosine phosphorylation has been implicated in normal and pathological functions
such as cell proliferation, migration and differentiation. Recently, some studies have shown …

Hypersensitivity to mechanical stimulation is a well documented symptom of neuropathic
pain, for which there is currently no effective therapy. Src-family kinases (SFKs) are involved …

It is now widely accepted that the glial cells of the central nervous system (CNS) are key
players in many processes, especially when they are activated via neuron-glia or glia-glia …

We examined the effect of p38 mitogen‐activated protein kinase (MAPK) inhibitors in models
of nociception and correlated this effect with localization and expression levels of p38 MAPK …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Stressful stimuli can exacerbate persistent pain disorder. However, the underlying
mechanism is still unknown. Here, to reveal the underlying mechanism for stressful stimuli …

Clinical studies indicate that psychosocial stress contributes to adverse chronic pain
outcomes in patients, but it is unclear how this is initiated or amplified by stress. Repeated …

Objective The present study aimed to investigate the potential roles of spinal microglia and
downstream molecules in the induction of spinal long-term potentiation (LTP) and …