[HTML][HTML] CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma

J Geng, L Chen, Y Yuan, K Wang, Y Wang… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,
compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth …

[HTML][HTML] Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

H Bian, ZH Zheng, D Wei, A Wen, Z Zhang… - Signal transduction and …, 2021 - nature.com
Abstracts Recent evidence suggests that CD147 serves as a novel receptor for severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti …

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

K Wang, W Chen, YS Zhou, JQ Lian, Z Zhang, P Du… - biorxiv, 2020 - biorxiv.org
Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific …

[HTML][HTML] CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

KE Wang, W Chen, Z Zhang, Y Deng, JQ Lian… - Signal transduction and …, 2020 - nature.com
In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no
specific and effective drugs for treating this disease have been reported until today …

Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial

H Bian, ZH Zheng, D Wei, Z Zhang, WZ Kang, CQ Hao… - medrxiv, 2020 - medrxiv.org
Background SARS-CoV-2 is a novel human coronavirus, there is no specific antiviral drugs.
It has been proved that host-cell-expressed CD147 could bind spike protein of SARS-CoV-2 …

[HTML][HTML] SARS-CoV-2 entry: at the crossroads of CD147 and ACE2

C Fenizia, S Galbiati, C Vanetti, R Vago, M Clerici… - Cells, 2021 - mdpi.com
In late 2019, the betacoronavirus SARS-CoV-2 was identified as the viral agent responsible
for the coronavirus disease 2019 (COVID-19) pandemic. Coronaviruses Spike proteins are …

[HTML][HTML] CD147 as a target for COVID-19 treatment: suggested effects of azithromycin and stem cell engagement

H Ulrich, MM Pillat - Stem cell reviews and reports, 2020 - Springer
The expressive number of deaths and confirmed cases of SARS-CoV-2 call for an urgent
demand of effective and available drugs for COVID-19 treatment. CD147, a receptor on host …

[HTML][HTML] COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

P Maisonnasse, Y Aldon, A Marc, R Marlin… - Nature …, 2021 - nature.com
Abstract Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2
(SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results …

SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner

YQ Zhou, K Wang, XY Wang, HY Cui… - Emerging microbes & …, 2022 - Taylor & Francis
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its
variants is threatening public health around the world. Endocytosis functions as an important …

CD147-spike protein interaction in COVID-19: Get the ball rolling with a novel receptor and therapeutic target

T Behl, I Kaur, L Aleya, A Sehgal, S Singh… - Science of the Total …, 2022 - Elsevier
The combat against the Corona virus disease of 2019 (COVID-19), has created a chaos
among the healthcare institutions and researchers, in turn accelerating the dire need to …