Immunological memory is a defining feature of vertebrate physiology, allowing rapid
responses to repeat infections. However, the molecular mechanisms required for its …

We have identified a simple epigenetic mechanism underlying the establishment and
maintenance of immunological memory in T cells. By studying the transcriptional regulation …

How the immune system remembers a previous encounter with a pathogen and responds
more efficiently to a subsequent encounter has been one of the central enigmas for …

Clonal expansion and immunological memory are hallmark features of the mammalian
adaptive immune response and essential for prolonged host control of pathogens. Recent …

Immunological memory is a cardinal feature of adaptive immunity and an important goal of
vaccination strategies. Here we highlight advances in the understanding of the diverse T …

The ability of vertebrates to 'remember'previous infections had once been attributed
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …

The conceptualization of adaptive immunity, founded on the observation of immunological
memory, has served as the basis for modern vaccination and immunotherapy approaches …

Experienced T cells exhibit immunological memory via a rapid recall response, responding
to restimulation much faster than naïve T cells. The formation of immunological memory …

T‐cell‐based immunological memory has the potential to provide the host with life‐long
protection against pathogen reexposure and thus offers tremendous promise for the design …

Highlights•Organisms lacking an adaptive immune system can mount resistance to
secondary infections.•NK cells and monocytes have adaptive (memory) characteristics.• …