Impaired cellular immunity to SARS-CoV-2 in severe COVID-19 patients

L Ni, ML Cheng, Y Feng, H Zhao, J Liu, F Ye… - Frontiers in …, 2021 - frontiersin.org
The high infection rate and rapid spread of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) make it a world-wide pandemic. Individuals infected by the virus exhibited …

[PDF][PDF] Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

M Koutsakos, LC Rowntree, L Hensen, BY Chua… - Cell Reports …, 2021 - cell.com
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …

Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection

R Wang, Y Han, R Zhang, J Zhu, X Nan, Y Liu, Z Yang… - Immunity, 2023 - cell.com
The 2003 severe acute respiratory syndrome coronavirus (SARS-CoV-1) causes more
severe disease than SARS-CoV-2, which is responsible for COVID-19. However, our …

Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome

D Weiskopf, KS Schmitz, MP Raadsen, A Grifoni… - Science …, 2020 - science.org
SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory
tract disease (COVID-19). In some patients, the infection results in moderate to severe acute …

[HTML][HTML] Humoral immune responses in COVID-19 patients: a window on the state of the art

G Siracusano, C Pastori, L Lopalco - Frontiers in immunology, 2020 - frontiersin.org
The novel SARS-CoV-2 is a recently emerging virus causing a human pandemic. A great
variety of symptoms associated with COVID-19 disease, ranging from mild to severe …

[PDF][PDF] Cell-type-specific immune dysregulation in severely ill COVID-19 patients

C Yao, SA Bora, T Parimon, T Zaman, OA Friedman… - Cell reports, 2021 - cell.com
Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …

The deciphering of the immune cells and marker signature in COVID‐19 pathogenesis: An update

SA Jasim, RS Mahdi, DO Bokov… - Journal of Medical …, 2022 - Wiley Online Library
The precise interaction between the immune system and severe acute respiratory syndrome
coronavirus 2 (SARS‑CoV‑2) is critical in deciphering the pathogenesis of coronavirus …

Different innate and adaptive immune responses to SARS-CoV-2 infection of asymptomatic, mild, and severe cases

R Carsetti, S Zaffina, E Piano Mortari, S Terreri… - Frontiers in …, 2020 - frontiersin.org
SARS-CoV-2 is a novel coronavirus, not encountered before by humans. The wide spectrum
of clinical expression of SARS-CoV-2 illness suggests that individual immune responses to …

Deciphering the role of host genetics in susceptibility to severe COVID-19

ME Carter-Timofte, SE Jørgensen, MR Freytag… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following
infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst …

COVID-19: Immunology and treatment options

S Felsenstein, JA Herbert, PS McNamara… - Clinical …, 2020 - Elsevier
The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. As
protective immunity does not exist in humans and the virus is capable of escaping innate …