Divergent SARS‐CoV‐2‐specific T‐and B‐cell responses in severe but not mild COVID‐19 patients
AE Oja, A Saris, CA Ghandour… - European journal of …, 2020 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the current coronavirus disease 2019 (COVID‐19) pandemic. Understanding the immune …
the current coronavirus disease 2019 (COVID‐19) pandemic. Understanding the immune …
[HTML][HTML] SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity
Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …
Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
[HTML][HTML] COVID-19: immunopathology and its implications for therapy
X Cao - Nature reviews immunology, 2020 - nature.com
Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia,
exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; …
exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; …
[HTML][HTML] The intersection of COVID-19 and autoimmunity: What is our current understanding?
N Winchester, C Calabrese… - Pathogens and Immunity, 2021 - ncbi.nlm.nih.gov
Viral infections have historically had a complex relationship with autoimmune diseases. For
patients with preexisting autoimmune disorders, often complicated by immunosuppressive …
patients with preexisting autoimmune disorders, often complicated by immunosuppressive …
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm
PA Mudd, JC Crawford, JS Turner, A Souquette… - Science …, 2020 - science.org
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …
Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19
NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
Comprehensive mapping of immune perturbations associated with severe COVID-19
L Kuri-Cervantes, MB Pampena, W Meng… - Science …, 2020 - science.org
Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
[HTML][HTML] COVID-19: The emerging immunopathological determinants for recovery or death
Hyperactivation of the host immune system during infection by SARS-CoV-2 is the leading
cause of death in COVID-19 patients. It is also evident that patients who develop …
cause of death in COVID-19 patients. It is also evident that patients who develop …
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
INTRODUCTION A systematic characterization of the humoral response to severe acute
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …