Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus

Y Zhou, B Fu, X Zheng, D Wang, C Zhao, Y Qi, R Sun… - biorxiv, 2020 - biorxiv.org
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …

Severe acute respiratory syndrome (SARS) coronavirus-induced lung epithelial cytokines exacerbate SARS pathogenesis by modulating intrinsic functions of …

T Yoshikawa, T Hill, K Li, CJ Peters… - Journal of virology, 2009 - Am Soc Microbiol
Severe acute respiratory syndrome (SARS), which is caused by a novel coronavirus (CoV),
is a highly communicable disease with the lungs as the major pathological target. Although …

[HTML][HTML] Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …

Monocytes and macrophages, targets of severe acute respiratory syndrome coronavirus 2: the clue for coronavirus disease 2019 immunoparalysis

A Boumaza, L Gay, S Mezouar, E Bestion… - The Journal of …, 2021 - academic.oup.com
Abstract Background Coronavirus disease 2019 (COVID-19) clinical expression is
pleiomorphic, severity is related to age and comorbidities such as diabetes and …

A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses

SY Fung, KS Yuen, ZW Ye, CP Chan… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT World Health Organization has declared the ongoing outbreak of coronavirus
disease 2019 (COVID-19) a Public Health Emergency of International Concern. The virus …

Comparison of clinical and pathological features between severe acute respiratory syndrome and coronavirus disease 2019

T Zhang, LX Sun, RE Feng - Zhonghua jie he he hu xi za zhi …, 2020 - europepmc.org
Severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19)
shared similar pathogenetic, clinical and pathological features. Fever and cough were the …

SARS-CoV regulates immune function-related gene expression in human monocytic cells

W Hu, YT Yen, S Singh, CL Kao, BA Wu-Hsieh - Viral immunology, 2012 - liebertpub.com
Severe acute respiratory syndrome (SARS) is characterized by acute respiratory distress
syndrome (ARDS) and pulmonary fibrosis, and monocytes/macrophages are the key players …

Attenuated interferon and proinflammatory response in SARS-CoV-2–infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation

D Yang, H Chu, Y Hou, Y Chai, H Shuai… - The Journal of …, 2020 - academic.oup.com
Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic
virus shedding, nonspecific pharyngitis, to pneumonia with silent hypoxia and respiratory …

[HTML][HTML] A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection

LFP Ng, ML Hibberd, EE Ooi, KF Tang, SY Neo… - BMC infectious …, 2004 - Springer
Background The molecular basis of severe acute respiratory syndrome (SARS) coronavirus
(CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory …

[HTML][HTML] SARS coronavirus 2: from genome to infectome

M Rastogi, N Pandey, A Shukla, SK Singh - Respiratory research, 2020 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to the group of
Betacoronaviruses. The SARS-CoV-2 is closely related to SARS-CoV-1 and probably …