The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

Immunopathogenesis of coronavirus-induced acute respiratory distress syndrome (ARDS): potential infection-associated hemophagocytic lymphohistiocytosis

C Quan, C Li, H Ma, Y Li, H Zhang - Clinical Microbiology Reviews, 2020 - Am Soc Microbiol
The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China,
introduced the third highly pathogenic coronavirus into humans in the 21st century. Scientific …

In the eye of the COVID-19 cytokine storm

N Vaninov - Nature Reviews Immunology, 2020 - nature.com
Acute respiratory distress syndrome (ARDS) and robust cytokine storm are the hallmark of
severe COVID-19 cases. Using single-cell RNA sequencing of bronchoalveolar lavage fluid …

Pro-and anti-inflammatory responses in severe COVID-19-induced acute respiratory distress syndrome—an observational pilot study

Q Notz, M Schmalzing, F Wedekink… - Frontiers in …, 2020 - frontiersin.org
Objectives The severity of Coronavirus Disease 2019 (COVID-19) is largely determined by
the immune response. First studies indicate altered lymphocyte counts and function …

Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome

D Weiskopf, KS Schmitz, MP Raadsen, A Grifoni… - Science …, 2020 - science.org
SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory
tract disease (COVID-19). In some patients, the infection results in moderate to severe acute …

[HTML][HTML] Severe acute respiratory syndrome-related coronavirus: The species and its viruses–a statement of the Coronavirus Study Group

AE Gorbalenya, SC Baker, RS Baric, RJ de Groot… - BioRxiv, 2020 - biorxiv.org
The present outbreak of lower respiratory tract infections, including respiratory distress
syndrome, is the third spillover, in only two decades, of an animal coronavirus to humans …

SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients

MC Pontelli, ÍA Castro, RB Martins… - Journal of Molecular …, 2022 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated
with a hyperinflammatory state and lymphocytopenia, a hallmark that appears as both …

Evidence of severe acute respiratory syndrome coronavirus 2 replication and tropism in the lungs, airways, and vascular endothelium of patients with fatal coronavirus …

J Bhatnagar, J Gary, S Reagan-Steiner… - The Journal of …, 2021 - academic.oup.com
Background The coronavirus disease 2019 (COVID-19) pandemic continues to produce
substantial morbidity and mortality. To understand the reasons for the wide-spectrum …

Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection

T Yoshikawa, TE Hill, N Yoshikawa, VL Popov… - PloS one, 2010 - journals.plos.org
Human lung epithelial cells are likely among the first targets to encounter invading severe
acute respiratory syndrome-associated coronavirus (SARS-CoV). Not only can these cells …

No evidence for human monocyte-derived macrophage infection and antibody-mediated enhancement of SARS-CoV-2 infection

O García-Nicolás, P V'kovski, F Zettl… - Frontiers in cellular …, 2021 - frontiersin.org
Vaccines are essential to control the spread of severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) and to protect the vulnerable population. However, one safety …