COVID-19: knowns, unknowns, and questions

S Weston, MB Frieman - Msphere, 2020 - Am Soc Microbiol
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
from the Hubei province in China in late 2019 demonstrates the epidemic potential of …

[HTML][HTML] Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-κB

X Zhang, K Wu, D Wang, X Yue, D Song, Y Zhu, J Wu - Virology, 2007 - Elsevier
High levels of interleukin-6 (IL-6) in the acute stage associated with lung lesions were found
in SARS patients. To evaluate the mechanisms behind this event, we investigated the roles …

Markers of immune activation and inflammation in individuals with postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection

MJ Peluso, S Lu, AF Tang… - The Journal of …, 2021 - academic.oup.com
Background The biological processes associated with postacute sequelae of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) are unknown. Methods …

[HTML][HTML] SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

NS Ogando, TJ Dalebout… - Journal of General …, 2020 - microbiologyresearch.org
The sudden emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
at the end of 2019 from the Chinese province of Hubei and its subsequent pandemic spread …

Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

J Zhang, H Wu, XH Yao, D Zhang, Y Zhou… - Cellular & molecular …, 2021 - nature.com
Coronavirus disease 2019 (COVID-19) is an unprecedented pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of 22 February 2021, the …

Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice …

F Yasui, C Kai, M Kitabatake, S Inoue… - The Journal of …, 2008 - journals.aai.org
The details of the mechanism by which severe acute respiratory syndrome-associated
coronavirus (SARS-CoV) causes severe pneumonia are unclear. We investigated the …

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells

N Huot, C Planchais, P Rosenbaum, V Contreras… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes
undetectable in upper airways after a few days or weeks postinfection. Here we used a …

Cytokine regulation in SARS coronavirus infection compared to other respiratory virus infections

T Okabayashi, H Kariwa, S Yokota, S Iki… - Journal of medical …, 2006 - Wiley Online Library
The pathogenesis of severe acute respiratory syndrome (SARS) is poorly understood and
cytokine dysregulation has been suggested as one relevant mechanism to be explored. We …

Clinical and immunological features of severe and moderate coronavirus disease 2019

G Chen, DI Wu, W Guo, Y Cao… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-
19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in …

Epidemic history and evolution of an emerging threat of international concern, the severe acute respiratory syndrome coronavirus 2

M Giovanetti, F Branda, E Cella… - Journal of Medical …, 2023 - Wiley Online Library
This comprehensive review focuses on the severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) and its impact as the cause of the COVID‐19 pandemic. Its objective is to …