Targeting treatable traits in severe asthma: a randomised controlled trial

VM McDonald, VL Clark… - European …, 2020 - Eur Respiratory Soc
Rationale Treatable traits have been proposed as a new paradigm for airway disease
management. Objectives To characterise treatable traits in a severe asthma population and …

Treatable traits can be identified in a severe asthma registry and predict future exacerbations

VM McDonald, SA Hiles, K Godbout, ES Harvey… - …, 2019 - Wiley Online Library
Background and objective A new taxonomic and management approach, termed treatable
traits, has been proposed for airway diseases including severe asthma. This study examined …

Identification of asthma phenotypes based on extrapulmonary treatable traits

PD Freitas, RF Xavier, VM McDonald… - European …, 2021 - Eur Respiratory Soc
Asthma is a heterogeneous and complex disease, and a description of asthma phenotypes
based on extrapulmonary treatable traits has not been previously reported. The objective of …

[HTML][HTML] An algorithmic approach for the treatment of severe uncontrolled asthma

E Zervas, K Samitas, AI Papaioannou… - ERJ open …, 2018 - Eur Respiratory Soc
A small subgroup of patients with asthma suffers from severe disease that is either partially
controlled or uncontrolled despite intensive, guideline-based treatment. These patients have …

Treatable traits that predict health status and treatment response in airway disease

SA Hiles, PG Gibson, A Agusti, VM McDonald - The Journal of Allergy and …, 2021 - Elsevier
Background A strategy based on the assessment and management of treatable traits (TTs)
has been proposed as a new paradigm in airway disease. There is a potentially long list of …

Comorbid “treatable traits” in difficult asthma: current evidence and clinical evaluation

TR Tay, M Hew - Allergy, 2018 - Wiley Online Library
The care of patients with difficult‐to‐control asthma (“difficult asthma”) is challenging and
costly. Despite high‐intensity asthma treatment, these patients experience poor asthma …

Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report

VM McDonald, J Fingleton, A Agusti… - European …, 2019 - Eur Respiratory Soc
“Treatable traits” have been proposed as a new paradigm for the management of airway
diseases, particularly complex disease, which aims to apply personalised medicine to each …

[HTML][HTML] Moving towards a treatable traits model of care for the management of obstructive airways diseases

A Agusti, N Barnes, AA Cruz, PG Gibson, LG Heaney… - Respiratory …, 2021 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic
airways diseases. Both are complex and heterogeneous. Traditionally, clinical guidelines …

Multidimensional assessment of severe asthma: a systematic review and meta‐analysis

VL Clark, PG Gibson, G Genn, SA Hiles… - …, 2017 - Wiley Online Library
The management of severe asthma is complex. Multidimensional assessment (MDA) of
specific traits has been proposed as an effective strategy to manage severe asthma …

[HTML][HTML] Diagnosis and treatment of severe asthma: a phenotype-based approach

TL Jones, DM Neville, AJ Chauhan - Clinical Medicine, 2018 - Elsevier
Severe asthma is a heterogeneous and often difficult to treat condition that results in a
disproportionate cost to healthcare systems. Appropriate diagnosis and management of …