The dramatic rise in microbial drug resistance in recent years has led to ongoing searches
for novel drugs to add to the armory against infectious disease. Nevertheless, a paucity of …

The continued increase in antibiotic resistance among bacterial pathogens, coupled with a
decrease in infectious disease research among pharmaceutical companies, has escalated …

There is a need to develop novel antibiotics for treating infections caused by multiresistant
pathogens. Notwithstanding a plethora of novel targets and intensive high-throughput …

We describe an ultra‐high‐throughput screening platform enabling discovery and/or
engineering of natural product antibiotics. The methodology involves creation of hydrogel‐in …

It has been nearly 50 years since the golden age of antibiotic discovery (1945–1975) ended;
yet, we still struggle to identify novel drug targets and to deliver new chemical classes of …

The emergence of multi-drug resistant bacteria is one of the most critical medical problems
currently facing humankind, which will only get worse if no new antibacterial drugs are …

During the last decade the field of antibacterial drug discovery has changed in many aspects
including bacterial organisms of primary interest, discovery strategies applied and …

The modern era of antibacterial chemotherapy began in the 1930s, and the next four
decades saw the discovery of almost all the major classes of antibacterial agents that are …

Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time,
little progress has been made in discovering new antibacterial drugs to combat resistant …

The discovery of novel antibiotics is essential to combat the rise of antimicrobial resistance.
While a number of initiatives are focused on advancing promising leads into the clinic, there …