Disrupting binocular vision during a developmental critical period can yield enduring
changes to ocular dominance (OD) in primary visual cortex (V1). Here we investigated how …

A characteristic of the developing mammalian visual system is a brief interval of plasticity,
termed the “critical period,” when the circuitry of primary visual cortex is most sensitive to …

The closure of developmental critical periods consolidates neural circuitry but also limits
recovery from early abnormal sensory experience. Degrading vision by one eye throughout …

During the developmental critical period for visual plasticity, discordant vision alters the
responsiveness of neurons in visual cortex. The subsequent closure of the critical period not …

Degrading vision by one eye during a developmental critical period yields enduring deficits
in both eye dominance and visual acuity. A predominant model is that" reactivating" ocular …

Monocular deprivation normally alters ocular dominance in the visual cortex only during a
postnatal critical period (20 to 32 days postnatal in mice). We find that mutations in the Nogo …

Monocular deprivation (MD) during the critical period (CP) shifts ocular dominance (OD) of
cortical responsiveness toward the nondeprived eye. The synaptic mechanisms underlying …

The formation and stability of dendritic spines on excitatory cortical neurons are correlated
with adult visual plasticity, yet how the formation, loss, and stability of postsynaptic spines …

Classical studies on the development of ocular dominance (OD) organization in primary
visual cortex (V1) have revealed a postnatal critical period (CP), during which visual inputs …

Postnatal cortical circuit development is characterized by windows of heightened plasticity
that contribute to the acquisition of mature connectivity and function. What drives the …