Background Despite strong evidence of heritability, few studies have attempted to unveil the
genetic underpinnings of testosterone levels. Objective To identify testosterone-associated …

Background Evolutionary biology suggests growth and reproduction trade-off against
longevity. Correspondingly estrogen supplementation failed to increase lifespan …

Abstract Background and Objectives Testosterone plays an important role in regulating male
development, reproduction and health. Declining levels across the lifespan may reflect, or …

Objectives The overall study aim is to clarify the relation of endogenous sex hormones with
major health outcomes in men. This paper reports a systematic review focusing on …

Background Effective prevention of type 2 diabetes (T2D) requires early identification of high-
risk individuals who might benefit from intervention. We sought to determine whether low …

Background: The relationship between age-associated dec-line of testosterone (T),
cardiovascular (CV) risk and sexual dysfunction in males is not completely clear. The aim of …

Background The relation between testosterone (T) plasma concentration and cardiovascular
(CV) risk is unclear, with evidence supporting increased risk in men with low and high T …

Prospective studies showed that low serum testosterone concentrations are associated with
various cardiometabolic risk factors and mortality. However, the causal nature of these …

Background The genetic underpinning of sexual dimorphism is very poorly understood. The
prevalence of many diseases differs between men and women, which could be in part …

Objective To determine whether endogenous testosterone has a causal role in
thromboembolism, heart failure, and myocardial infarction. Design Two sample mendelian …