Genetic influences on testosterone and PTSD

SE Cusack, AX Maihofer, D Bustamante… - Journal of Psychiatric …, 2024 - Elsevier
Females are twice as likely to experience PTSD as compared to males. Although sex
differences in prevalence are well-established, little is known about why such sex …

Factors associated with circulating sex hormones in men: individual participant data meta-analyses

RJ Marriott, K Murray, RJ Adams, L Antonio… - Annals of internal …, 2023 - acpjournals.org
Background: Various factors modulate circulating testosterone in men, affecting
interpretation of testosterone measurements. Purpose: To clarify factors associated with …

Cross-ancestry genome-wide association studies of sex hormone concentrations in pre-and postmenopausal women

CB Haas, L Hsu, JW Lampe, KJ Wernli… - …, 2022 - academic.oup.com
Objective Concentrations of circulating sex hormones have been associated with a variety of
diseases in women and are strongly influenced by menopausal status. We investigated the …

[HTML][HTML] Testosterone levels and type 2 diabetes—no correlation with age, differential predictive value in men and women

M Karakas, S Schäfer, S Appelbaum, F Ojeda… - Biomolecules, 2018 - mdpi.com
Most studies reporting on the association of circulating testosterone levels with type 2
diabetes in men are of cross-sectional design. Reports on the relevance of altered …

Developing a transcriptomic framework for testing testosterone-mediated handicap hypotheses

DJ Newhouse, BJ Vernasco - General and Comparative Endocrinology, 2020 - Elsevier
Sexually selected traits are hypothesized to be honest signals of individual quality due to the
costs associated with their maintenance, development, and/or production. Testosterone, a …

Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans

A Chakrabarty, S Chakraborty… - Proceedings of the …, 2024 - National Acad Sciences
Sex difference (SD) is ubiquitous in humans despite shared genetic architecture (SGA)
between the sexes. A univariate approach, ie, studying SD in single traits by estimating …

Genetic mechanisms leading to sex differences across common diseases and anthropometric traits

M Traglia, D Bseiso, A Gusev, B Adviento, DS Park… - Genetics, 2017 - academic.oup.com
Common diseases often show sex differences in prevalence, onset, symptomology,
treatment, or prognosis. Although studies have been performed to evaluate sex differences …

[HTML][HTML] Testosterone level reduction increases the 10-year risk of cardiovascular diseases: A retrospective cohort study in a taiwanese young male population

HH Yang, SK Tu, HH Chen, CL Hung… - Frontiers in …, 2022 - frontiersin.org
Low testosterone levels are associated with increased risk of cardiovascular disease;
however, most previous studies assessed the relationship of testosterone levels with a …

[HTML][HTML] Genetically predicted alterations in thyroid function are associated with the risk of benign prostatic disease

Y Huang, C Chen, W Zhou, Q Zhang, Y Zhao… - Frontiers in …, 2023 - frontiersin.org
Background Benign prostatic diseases (BPDs), such as benign prostate hyperplasia (BPH)
and prostatitis, harm the quality of life of affected patients. However, observational studies …

[HTML][HTML] Associations between serum sex hormone concentrations and whole blood gene expression profiles in the general population

R Haring, C Schurmann, G Homuth, L Steil, U Völker… - PloS one, 2015 - journals.plos.org
Background Despite observational evidence from epidemiological and clinical studies
associating sex hormones with various cardiometabolic risk factors or diseases …