Although reduced testosterone levels are common in aging populations, the clinical
consequences remain to be further explored. We examined whether low total testosterone …

Although observational studies have explored factors that may be associated with
osteoporosis, it is not clear whether they are causal. Osteoporosis in men is often …

The role of testosterone (T) in the cardiovascular (CV) health of men is controversial. Some
data suggest that hypogonadism is associated with CV mortality but not morbidity, however …

Background Although observational studies have shown an association between sex
hormone-binding globulin (SHBG), testosterone (T) and cardiovascular diseases (CVD) …

Testosterone is a pleiotropic hormone that plays an important role in the human body.
Classically, testosterone was thought to be predominantly involved in androgenesis and …

Roach et al.[1] systematically review environmental and genetic risk factors for venous
thrombosis to elucidate the greater vulnerability to first and recurrent venous thrombosis in …

Context: Low sex hormone levels have been associated with the metabolic syndrome
(MetS). Objectives: Our objective was to determine whether the association between sex …

Objectives: We tested the hypothesis that serum total testosterone and sex hormone–
binding globulin (SHBG) levels predict cardiovascular (CV) events in community-dwelling …

Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …

Introduction Biological sex influences both overall adiposity and fat distribution. Further,
testosterone and sex hormone binding globulin (SHBG) influence adiposity and metabolic …