Sex steroid hormones are associated with chronic diseases and mortality with risk
associations that differ between racial and ethnic groups. However, it is currently unclear …

Context: The relationship between testosterone and diabetes in men is an important issue,
given that one third of US men aged 65 yr or older have diabetes, with a similar percentage …

In utero androgen excess reliably induces polycystic ovary syndrome (PCOS)-like
reproductive and metabolic traits in female monkeys, sheep, rats, and mice. In humans …

Research is increasingly focusing on promoting healthy aging and the related extension of
the health span by targeting crucial biological processes responsible for age-related …

Background Lower testosterone levels in men have been consistently associated with
metabolic abnormalities, particularly obesity. This study aims to investigate the relationship …

Context: Low serum T levels have been associated with type 2 diabetes (T2D) and
cardiovascular disease. However, it is unresolved whether low T is a risk factor or rather a …

Phenotypic differences across sexes are pervasive, but the genetic architecture of sex
differences within and across phenotypes is mostly unknown. In this study, we aimed to …

Testosterone replacement for older men is increasingly common, with some observations
suggesting a protective effect on cognitive function. We examined the association of …

Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …

Background Despite the high prevalence of depressive symptoms in women, the precise
role of sex hormones in mood changes during the menopausal transition is unclear …