MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide

VM Bashyam, G Erus, J Doshi, M Habes, IM Nasrallah… - Brain, 2020 - academic.oup.com
Deep learning has emerged as a powerful approach to constructing imaging signatures of
normal brain ageing as well as of various neuropathological processes associated with …

Estimating brain age based on a uniform healthy population with deep learning and structural magnetic resonance imaging

X Feng, ZC Lipton, J Yang, SA Small… - Neurobiology of …, 2020 - Elsevier
Numerous studies have established that estimated brain age constitutes a valuable
biomarker that is predictive of cognitive decline and various neurological diseases. In this …

Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment

C Yin, P Imms, M Cheng, A Amgalan… - Proceedings of the …, 2023 - National Acad Sciences
The gap between chronological age (CA) and biological brain age, as estimated from
magnetic resonance images (MRIs), reflects how individual patterns of neuroanatomic aging …

[HTML][HTML] Local brain-age: a U-net model

SG Popescu, B Glocker, DJ Sharp… - Frontiers in Aging …, 2021 - frontiersin.org
We propose a new framework for estimating neuroimaging-derived “brain-age” at a local
level within the brain, using deep learning. The local approach, contrary to existing global …

Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker

JH Cole, RPK Poudel, D Tsagkrasoulis, MWA Caan… - NeuroImage, 2017 - Elsevier
Abstract Machine learning analysis of neuroimaging data can accurately predict
chronological age in healthy people. Deviations from healthy brain ageing have been …

[HTML][HTML] Deep neural networks learn general and clinically relevant representations of the ageing brain

EH Leonardsen, H Peng, T Kaufmann, I Agartz… - NeuroImage, 2022 - Elsevier
The discrepancy between chronological age and the apparent age of the brain based on
neuroimaging data—the brain age delta—has emerged as a reliable marker of brain health …

[HTML][HTML] Openbhb: a large-scale multi-site brain mri data-set for age prediction and debiasing

B Dufumier, A Grigis, J Victor, C Ambroise, V Frouin… - NeuroImage, 2022 - Elsevier
Prediction of chronological age from neuroimaging in the healthy population is an important
issue because the deviations from normal brain age may highlight abnormal trajectories …

[HTML][HTML] Accurate brain‐age models for routine clinical MRI examinations

DA Wood, S Kafiabadi, A Al Busaidi, E Guilhem… - Neuroimage, 2022 - Elsevier
Convolutional neural networks (CNN) can accurately predict chronological age in healthy
individuals from structural MRI brain scans. Potentially, these models could be applied …

[HTML][HTML] Learning patterns of the ageing brain in MRI using deep convolutional networks

NK Dinsdale, E Bluemke, SM Smith, Z Arya, D Vidaurre… - NeuroImage, 2021 - Elsevier
Both normal ageing and neurodegenerative diseases cause morphological changes to the
brain. Age-related brain changes are subtle, nonlinear, and spatially and temporally …

Multi-channel attention-fusion neural network for brain age estimation: Accuracy, generality, and interpretation with 16,705 healthy MRIs across lifespan

S He, D Pereira, JD Perez, RL Gollub, SN Murphy… - Medical Image …, 2021 - Elsevier
Brain age estimated by machine learning from T1-weighted magnetic resonance images
(T1w MRIs) can reveal how brain disorders alter brain aging and can help in the early …