Inefficient splicing of long non-coding RNAs is associated with higher transcript complexity in human and mouse

K Basu, A Dey, M Kiran - RNA biology, 2023 - Taylor & Francis
Recent reports show that long non-coding RNAs (lncRNAs) have inefficient splicing and
fewer alternative splice variants than mRNAs. Here, we have explored the efficiency of …

Exploring the alternative splicing of long noncoding RNAs

MR Khan, RJ Wellinger, B Laurent - Trends in Genetics, 2021 - cell.com
Like protein-coding genes, long noncoding RNA (lncRNA) genes are composed of introns
and exons. After their transcription, lncRNAs are subject to constitutive and/or alternative …

Splicing of long non-coding RNAs primarily depends on polypyrimidine tract and 5′ splice-site sequences due to weak interactions with SR proteins

Z Krchňáková, PK Thakur, M Krausová… - Nucleic acids …, 2019 - academic.oup.com
Many nascent long non-coding RNAs (lncRNAs) undergo the same maturation steps as pre-
mRNAs of protein-coding genes (PCGs), but they are often poorly spliced. To identify the …

Long non-coding RNAs and splicing

D Staněk - Essays in biochemistry, 2021 - portlandpress.com
In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I
summarize differences between the splicing efficiency of protein-coding genes and lncRNAs …

Splicing noncoding RNAs from the inside out

L Yang - Wiley Interdisciplinary Reviews: RNA, 2015 - Wiley Online Library
Eukaryotic precursor‐messenger RNAs (pre‐mRNAs) undergo splicing to remove intragenic
regions (introns) and ligate expressed regions (exons) together. Unlike exons in the mature …

Splicing regulation by long noncoding RNAs

N Romero-Barrios, MF Legascue… - Nucleic acids …, 2018 - academic.oup.com
Massive high-throughput sequencing techniques allowed the identification of thousands of
noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in …

[HTML][HTML] Alternative splicing of lncRNAs in human diseases

J Chen, Y Liu, J Min, H Wang, F Li, C Xu… - American journal of …, 2021 - ncbi.nlm.nih.gov
Alternative splicing (AS), a vital post-transcription process for eukaryote gene expression
regulating, can efficiently improve gene utilization and increase the variety of RNA …

Epigenetic regulation of alternative splicing: how LncRNAs tailor the message

G Pisignano, M Ladomery - Non-coding RNA, 2021 - mdpi.com
Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of
proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is …

Regulation of alternative splicing by short non-coding nuclear RNAs

A Khanna, S Stamm - RNA biology, 2010 - Taylor & Francis
Recent results from deep-sequencing and tiling array studies indicated the existence of a
large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs …

Distinct regulatory functions and biological roles of lncRNA splice variants

MR Khan, M Avino, RJ Wellinger, B Laurent - Molecular Therapy-Nucleic …, 2023 - cell.com
Alternative splicing (AS) of RNA molecules is a key contributor to transcriptome diversity. In
humans, 90%–95% of multi-exon genes produce alternatively spliced RNA transcripts …