Simple Summary Interleukin-1 cytokines are key proinflammatory cytokines which have
been implicated with differing pro-and antitumorigenic properties. Recent years have …

Introduction It is now clear that inflammation and cancer initiation and progression are
linked. Interleukin-6 (IL-6) is a pleiotropic inflammatory cytokine with described cancer …

We examined the autocrine/paracrine role of interleukin-8 (CXCL8) and the functional
significance of CXCL8 receptors, CXCR1 and CXCR2, in human malignant melanoma …

Many clinical conditions including various types of cancers are complex and generally
require invasive, laborious, expensive and time-consuming investigations for their …

Growing evidence proposes an important role for pro-inflammatory cytokines during tumor
development. Several experimental and clinical studies have linked the pleiotropic cytokine …

Paclitaxel is a frontline therapy for ovarian cancer. Our laboratory has shown that paclitaxel
induces IL-8, a member of the CXC family of chemokines, in subsets of human ovarian …

Cytokines play a critical role in regulating host immune response toward cancer and
determining the overall fate of tumorigenesis. The tumor microenvironment is dominated …

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …

Early in the 1980s several laboratories mistakenly reported that partially purified interleukin-
1 (IL-1) was chemotactic for neutrophils. However, further investigations by us, revealed that …

Interleukin 6 (IL-6), a pleiotropic protein of about 26 kDa molecular weight, plays a role in
diverse organ systems. These activities range from such proinflammatory activities as …