Can Systemic Diseases Co-induce (Not Just Exacerbate) Periodontitis? A Hypothetical “Two-hit” Model

LM Golub, JB Payne, RA Reinhardt… - Journal of dental …, 2006 - journals.sagepub.com
The connection between systemic diseases and chronic destructive periodontitis (CDP) has
received increasing attention in recent years. A major unanswered question is how disease …

The two‐way association of periodontal infection with systemic disorders: An overview

R Nagpal, Y Yamashiro, Y Izumi - Mediators of inflammation, 2015 - Wiley Online Library
Oral cavity that harbors diverse bacterial populations could also act as a site of origin for
spread of pathogenic microorganisms to different body sites, particularly in …

The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm

RC Page - Annals of periodontology, 1998 - Wiley Online Library
A new paradigm for the pathobiology of periodontitis is presented, and the manner in which
periodontitis may relate to susceptibility for certain systemic diseases such as cardiovascular …

Systemic effects of periodontal diseases

FA Scannapieco - Dental Clinics, 2005 - dental.theclinics.com
The possibility that a localized oral condition such as periodontal disease (PD) may have
systemic effects seems to be of interest to the average person. The notion that a condition …

Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

G Hajishengallis - Periodontology 2000, 2022 - Wiley Online Library
Periodontitis, a microbiome‐driven inflammatory disease of the tooth‐attachment apparatus,
is epidemiologically linked with other disorders, including cardio‐metabolic, cognitive …

Rethinking periodontal inflammation

S Offenbacher, SP Barros, JD Beck - Journal of periodontology, 2008 - Wiley Online Library
Clinical signs and symptoms, as well as medical and dental history, are all considered in the
clinical determination of gingival inflammation and periodontal disease severity. However …

Periodontal inflammation and systemic diseases: an overview

M Martínez-García, E Hernández-Lemus - Frontiers in physiology, 2021 - frontiersin.org
Periodontitis is a common inflammatory disease of infectious origins that often evolves into a
chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis …

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

I Lopez‐Oliva, J Malcolm, S Culshaw - Periodontology 2000, 2024 - Wiley Online Library
Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to
manage patients with both periodontitis and RA. This review seeks to provide an update on …

Periodontal disease and systemic conditions: a bidirectional relationship

J Kim, S Amar - Odontology, 2006 - Springer
For decades, physicians and dentists have paid close attention to their own respective fields,
specializing in medicine pertaining to the body and the oral cavity, respectively. However …

Associations between periodontal disease and systemic disease: evaluating the strength of the evidence

T Dietrich, RI Garcia - Journal of periodontology, 2005 - Wiley Online Library
Much work has been published on the association between periodontal disease and
systemic disease, including original reports, narrative reviews, systematic reviews, and meta …