Background Netrin-1 is a laminin-related secreted protein, is highly induced after tissue
injury, and may serve as a marker of injury. However, the regulation of netrin-1 production is …

Netrin-1, a diffusible laminin-related protein, is highly expressed in the kidney. However, the
pathophysiological roles of netrin-1 in the kidney are unknown. To address this question …

Abstract Netrin-1, a multifunctional laminin-related protein is widely expressed in various
tissues, including kidney. The pathophysiological roles of netrin-1 in toxic acute kidney injury …

Acute kidney injury is an important complication in hospitalized patients often diagnosed late
and associated with high mortality and morbidity. Although biomarkers for nephrotoxicity are …

Currently available diagnostic markers representing kidney injury or function such as serum
creatinine and blood urea nitrogen are insensitive and often increased late in the disease …

The cellular hallmark of kidney repair is a rapid proliferation of renal tubular epithelial cells
ultimately leading to the restoration of nephron structure and function. Netrin-1 was …

Inflammation plays a key role in the development and progression of diabetic kidney
disease; however, the role of the anti-inflammatory molecule netrin-1 in diabetic kidney …

Endogenous mechanisms exist to limit inflammation. One such molecule is netrin. This study
examined the impact of ischemia-reperfusion (I/R) on netrin expression and the role of netrin …

The netrin family of secreted proteins provides migrational cues in the developing central
nervous system. Recently, netrins have also been shown to regulate diverse processes …

Background Netrin-1 was recently identified as an early diagnostic biomarker of acute
kidney injury. However, its usefulness for early diagnosis of CKD is unknown. The current …