The immune system is affected by the aging process and undergoes significant age-related
changes, termed immunosenescence. Different T cell subsets are affected by this process …

It is well-known that the functioning of the immune system gradually deteriorates with age,
and we are increasingly confronted with its consequences as the life expectancy of the …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

Longitudinal studies are defining progressive alterations to the immune system associated
with increased mortality in the very elderly. Many of these changes are exacerbated by or …

Aging is associated with a dysregulation of the immune response, loosely termed
“immunosenescence.” Each part of the immune system is influenced to some extent by the …

The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …

Decreased immune responsiveness associated with aging is generally termed
“immunosenescence”. Several theories have been proposed to explain age-related declines …

Immunosenescence comprises a set of dynamic changes occurring to both, the innate as
well as the adaptive immune system that accompany human aging and result in complex …