[HTML][HTML] Small molecular inhibitors block TRPM4 currents in prostate cancer cells, with limited impact on cancer hallmark functions
A Borgstroem, B Hauert, S Kappel, E Zoni… - Journal of molecular …, 2021 - Elsevier
Transient receptor potential melastatin 4 (TRPM4) is a broadly expressed Ca 2+ activated
monovalent cation channel that contributes to the pathophysiology of several diseases. For …
monovalent cation channel that contributes to the pathophysiology of several diseases. For …
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
AI Sagredo, EA Sagredo, V Pola… - Journal of Cellular …, 2019 - Wiley Online Library
Abstract Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+‐activated and voltage‐
dependent monovalent cation channel, which depolarizes the plasma cell membrane …
dependent monovalent cation channel, which depolarizes the plasma cell membrane …
TRPM8 puts the chill on prostate cancer
GP Grolez, D Gkika - Pharmaceuticals, 2016 - mdpi.com
Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed
countries. Several studies suggest that variations in calcium homeostasis are involved in …
countries. Several studies suggest that variations in calcium homeostasis are involved in …
[HTML][HTML] Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells
C Holzmann, S Kappel, T Kilch, MM Jochum… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Impaired Ca 2+ signaling in prostate cancer contributes to several cancer hallmarks, such as
enhanced proliferation and migration and a decreased ability to induce apoptosis. Na+ …
enhanced proliferation and migration and a decreased ability to induce apoptosis. Na+ …
Identification of a natural compound, sesamin, as a novel TRPM8 antagonist with inhibitory effects on prostate adenocarcinoma
Y Sui, S Li, Y Zhao, Q Liu, Y Qiao, L Feng, S Li - Fitoterapia, 2020 - Elsevier
Transient receptor potential melastatin 8 (TRPM8) is a calcium ion-permeable cation
channel that is used as a prognostic marker and therapeutic target for different tumor types …
channel that is used as a prognostic marker and therapeutic target for different tumor types …
TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells
Overexpression of the cation-permeable channel TRPM8 in prostate cancers might
represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of …
represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of …
PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression
Although the transient receptor potential melastatin 8 (TRPM8) cold receptor is highly
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …
[HTML][HTML] p53 alters intracellular Ca2+ signaling through regulation of TRPM4
S Kappel, D Ross-Kaschitza, B Hauert, K Rother… - Cell Calcium, 2022 - Elsevier
Altered expression of transient receptor potential channel melastatin 4 (TRPM4) contributes
to several diseases, including cardiac conduction disorders, immune diseases, and cancer …
to several diseases, including cardiac conduction disorders, immune diseases, and cancer …
Investigation of novel small molecular TRPM4 inhibitors in colorectal cancer cells
P Stokłosa, A Borgström, B Hauert, R Baur, C Peinelt - Cancers, 2021 - mdpi.com
Simple Summary Transient receptor potential melastatin 4 (TRPM4) ion channel malfunction
or aberrant expression is implicated in many diseases, including different cancers and …
or aberrant expression is implicated in many diseases, including different cancers and …
Trpm4 in cancer—a new potential drug target
A Borgström, C Peinelt, P Stokłosa - Biomolecules, 2021 - mdpi.com
Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …