Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …

Hydroxycholesterol (27HC) is an abundant cholesterol metabolite and has detrimental
effects on the cardiovascular system, whereas its impact on adiposity is not well known. In …

Background & Aims Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-
hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Increased adipose tissue macrophages (ATMs) correlate with metabolic dysfunction in
humans and are causal in development of insulin resistance in mice. Recent bulk and single …

Background Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder
that is characterised by dysfunctional lipid metabolism and cholesterol homeostasis, and a …

Obesity and diabetes are associated with inflammation and altered plasma levels of several
metabolites, which may be involved in disease progression. Some metabolites can activate …

Adipose tissue (AT) macrophages (ATMs) are key players for regulation of AT homeostasis
and obesity-related metabolic disorders. However, the phenotypes of human ATMs and …

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose
tissue dysfunction and contributing to obesity-induced inflammation and metabolic …

OBJECTIVE The study objective was to determine the key early mechanisms underlying the
beneficial redistribution, function, and inflammatory profile of adipose tissue in 11β …