Trial of galcanezumab in prevention of episodic cluster headache

PJ Goadsby, DW Dodick, M Leone… - … England Journal of …, 2019 - Mass Medical Soc
Background Episodic cluster headache is a disabling neurologic disorder that is
characterized by daily headache attacks that occur over periods of weeks or months …

Phase 3 randomized, placebo-controlled study of galcanezumab in patients with chronic cluster headache: results from 3-month double-blind treatment

DW Dodick, PJ Goadsby, C Lucas, R Jensen… - …, 2020 - journals.sagepub.com
Objective To report efficacy and safety of galcanezumab in adults with chronic cluster
headache. Background Galcanezumab is a humanized monoclonal antibody that binds to …

Pharmacotherapy for cluster headache

RB Brandt, PGG Doesborg, J Haan, MD Ferrari… - CNS drugs, 2020 - Springer
Cluster headache is characterised by attacks of excruciating unilateral headache or facial
pain lasting 15 min to 3 h and is seen as one of the most intense forms of pain. Cluster …

Effect of infusion of calcitonin gene-related peptide on cluster headache attacks: a randomized clinical trial

ALH Vollesen, A Snoer, RP Beske, S Guo… - JAMA …, 2018 - jamanetwork.com
Importance Signaling molecule calcitonin gene-related peptide (CGRP) induces migraine
attacks and anti-CGRP medications abort and prevent migraine attacks. Whether CGRP …

Evaluation of galcanezumab for the prevention of episodic migraine: the EVOLVE-1 randomized clinical trial

VL Stauffer, DW Dodick, Q Zhang, JN Carter… - JAMA …, 2018 - jamanetwork.com
Importance Migraine is a disabling neurological disease characterized by severe headache
attacks. Treatment options reduce migraine frequency for many patients, but adverse effects …

A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine

A Camporeale, D Kudrow, R Sides, S Wang… - BMC neurology, 2018 - Springer
Background Galcanezumab, a humanized monoclonal antibody that selectively binds to the
calcitonin gene-related peptide, has demonstrated in previous Phase 2 and Phase 3 clinical …

Efficacy and safety of galcanezumab for the prevention of episodic migraine: results of the EVOLVE-2 phase 3 randomized controlled clinical trial

V Skljarevski, M Matharu, BA Millen… - …, 2018 - journals.sagepub.com
Introduction Galcanezumab is a humanized monoclonal antibody binding calcitonin gene-
related peptide, used for migraine prevention. Methods A global, double-blind, 6-month …

Effect of different doses of galcanezumab vs placebo for episodic migraine prevention: a randomized clinical trial

V Skljarevski, TM Oakes, QI Zhang… - JAMA …, 2018 - jamanetwork.com
Importance Galcanezumab (LY2951742), a monoclonal antibody against calcitonin gene-
related peptide (CGRP), is one of a novel class of new medicines for migraine prevention …

European Academy of Neurology guidelines on the treatment of cluster headache

A May, S Evers, PJ Goadsby, M Leone… - European Journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Cluster headache is a relatively rare, disabling primary
headache disorder with a major impact on patients' quality of life. This work presents …

Rapid onset of effect of galcanezumab for the prevention of episodic migraine: analysis of the EVOLVE studies

HC Detke, BA Millen, Q Zhang… - … : The Journal of …, 2020 - Wiley Online Library
Objective To evaluate onset of effect of galcanezumab in patients with episodic migraine.
Background Galcanezumab is a monoclonal antibody that binds to calcitonin gene‐related …