Understanding the opposite effects of sex hormones in mediating renal injury

I Lima‐Posada, NA Bobadilla - Nephrology, 2021 - Wiley Online Library
According to epidemiological studies, chronic kidney disease (CKD) affects more women
than men, but the incidence of end‐stage renal disease is higher in men than in women …

Influence of sex on the progression of chronic kidney disease

J Neugarten, L Golestaneh - Mayo Clinic Proceedings, 2019 - Elsevier
The role that sex plays in the development and progression of chronic kidney disease
remains a subject of controversy. The lack of clarity in this important area reflects complex …

Gender and human chronic renal disease

S Silbiger, J Neugarten - Gender medicine, 2008 - Elsevier
Background: Gender affects the incidence, prevalence, and progression of renal disease. In
animal models of the disease, female sex appears to modify the course of progression …

Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes: TH-PO765

SC Freixas, M Kotlyar, CM McEvoy… - Journal of the …, 2022 - journals.lww.com
Background: Diabetic Kidney Disease (DKD) is recongnized as the leading cause of
Chronic Kidney Disease (CKD). Male sex is a risk factor for CKD, and is generally …

Effects of sex on renal structure

J Neugarten, B Kasiske, SR Silbiger, JR Nyengaard - Nephron, 2002 - karger.com
Aims: There are few data examining differences in renal structure between the sexes.
Elucidation of the mechanisms responsible for the observed effects of sex on the …

Role of sex hormones in prevalent kidney diseases

C Conte, G Antonelli, ME Melica, M Tarocchi… - International Journal of …, 2023 - mdpi.com
Chronic kidney disease (CKD) is a constantly growing global health burden, with more than
840 million people affected worldwide. CKD presents sex disparities in the pathophysiology …

Why do we keep ignoring sex in kidney disease?

M Jankowska, MJ Soler, KI Stevens… - Clinical Kidney …, 2023 - academic.oup.com
Throughout the history of nephrology, little attention has been paid to the sex and gender
differences in kidney disease. This lack of awareness prevents optimal diagnosis and …

Physiological and molecular mechanisms governing sexual dimorphism of kidney, cardiac, and vascular function

K Denton, C Baylis - American Journal of Physiology …, 2007 - journals.physiology.org
IT IS WELL ESTABLISHED THAT cardiovascular disease is a leading cause of death in
developed countries, but it is less well known that more women than men die of …

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

CM McEvoy, JM Murphy, L Zhang… - Nature …, 2022 - nature.com
Abstract Knowledge of the transcriptional programs underpinning the functions of human
kidney cell populations at homeostasis is limited. We present a single-cell perspective of …

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes …

M Scholz, K Horn, J Pott, M Wuttke, A Kühnapfel… - Nature …, 2024 - nature.com
X-chromosomal genetic variants are understudied but can yield valuable insights into
sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry …