Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies

S Safe, H Han, J Goldsby, K Mohankumar… - Current opinion in …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) binds structurally diverse ligands that vary from the
environmental toxicant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to AhR-active …

Analysis of the Aryl Hydrocarbon Receptor (Ah R) Signal Transduction Pathway

MS Denison, JM Rogers, SR Rushing… - Current protocols in …, 2002 - Wiley Online Library
Abstract Analysis of the Ah Receptor Signal Transduction Pathway (Michael S. Denison,
Jane M. Rohers, S. Renee Rushing. Carol L. Jones, Selwyna C. Tetangico, and Sharon …

Aryl hydrocarbon receptor: a new player of pathogenesis and therapy in cardiovascular diseases

T Yi, J Wang, K Zhu, Y Tang, S Huang… - BioMed research …, 2018 - Wiley Online Library
The aryl hydrocarbon receptor (AhR) is a DNA binding protein that acts as a nuclear
receptor mediating xenobiotic metabolism and environmental responses. Owing to the …

Detection of aryl hydrocarbon receptor agonists in human samples

V Rothhammer, DM Borucki, JE Kenison, P Hewson… - Scientific reports, 2018 - nature.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important
functions in the immune response and cancer. AHR agonists are provided by the …

A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo

EC Henry, JC Bemis, O Henry, AS Kende… - Archives of biochemistry …, 2006 - Elsevier
The aryl hydrocarbon receptor (AhR) is best known as a mediator of toxicity of a diverse
family of xenobiotic chemicals such as dioxins and PCBs. However, many naturally …

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice

JA Harrill, RR Hukkanen, M Lawson, G Martin… - Toxicology and applied …, 2013 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor which plays a
role in the development of multiple tissues and is activated by a large number of ligands …

A ligand for the aryl hydrocarbon receptor isolated from lung

J Song, M Clagett-Dame, RE Peterson… - Proceedings of the …, 2002 - National Acad Sciences
The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is best
known because it mediates the actions of polycyclic and halogenated aromatic hydrocarbon …

The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways

C Ma, JL Marlowe, A Puga - Molecular, Clinical and Environmental …, 2009 - Springer
The aryl hydrocarbon receptor (AHR) has long been recognized as a ligand-activated
transcription factor responsible for the induction of drug-metabolizing enzymes. Its role in the …

A structural switch between agonist and antagonist bound conformations for a ligand-optimized model of the human aryl hydrocarbon receptor ligand binding domain

A Perkins, JL Phillips, NI Kerkvliet, RL Tanguay… - Biology, 2014 - mdpi.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates
the expression of a diverse group of genes. Exogenous AHR ligands include the …

Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice

CA Flaveny, IA Murray, CR Chiaro, GH Perdew - Molecular pharmacology, 2009 - ASPET
The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that displays
interspecies differences with the human and mouse AHR C-terminal region sequences …