The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is essential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation

GD Minsavage, S Park, TA Gasiewicz - Journal of Biological Chemistry, 2004 - ASBMB
We delineate a mechanism by which dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin or TCDD)-
mediated formation of the aryl hydrocarbon receptor (AhR) DNA binding complex is …

Ligand binding and activation of the Ah receptor

MS Denison, A Pandini, SR Nagy, EP Baldwin… - Chemico-biological …, 2002 - Elsevier
The Ah receptor (AhR) is a ligand-dependent transcription factor that can be activated by
structurally diverse synthetic and naturally-occurring chemicals. Although a significant …

Aryl hydrocarbon receptor-mediated signal transduction

JC Rowlands, JÅ Gustafsson - Critical reviews in toxicology, 1997 - Taylor & Francis
The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix
(bHLH) protein that heterodimerizes with the bHLH protein ARNT (aryl hydrocarbon nuclear …

Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions

KW Bock - Biochemical Pharmacology, 2020 - Elsevier
Aryl hydrocarbon receptor (AHR) research has shifted from exploring dioxin toxicity to
elucidation of physiologic AHR functions. Control of AHR functions is challenged by the fact …

Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists

YF Lu, M Santostefano, BDM Cunningham… - Biochemical …, 1996 - Elsevier
The structure-dependent aryl hydrocarbon (Ah) receptor agonist and antagonist activities of
the following substituted flavones were investigated: flavone, 4′-methoxy-, 4′-amino-, 4 …

Binding mode and structure–activity relationships of ITE as an aryl hydrocarbon receptor (AhR) agonist

D Dolciami, M Gargaro, B Cerra, G Scalisi… - …, 2018 - Wiley Online Library
Discovered as a modulator of the toxic response to environmental pollutants, aryl
hydrocarbon receptor (AhR) has recently gained attention for its involvement in various …

Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of Ah receptor agonists

SR Nagy, JR Sanborn, BD Hammock… - Toxicological …, 2002 - academic.oup.com
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates
the toxic and biological effects of a variety of chemicals. Although halogenated and …

In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo

AJ Parks, MP Pollastri, ME Hahn, EA Stanford… - Molecular …, 2014 - ASPET
The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes,
including cancer progression and multiple immune system activities. We, and others, have …

AhR and cancer: from gene profiling to targeted therapy

A Paris, N Tardif, MD Galibert, S Corre - International journal of molecular …, 2021 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been
shown to be an essential regulator of a broad spectrum of biological activities required for …

Role of aryl hydrocarbon receptor in cancer

S Feng, Z Cao, X Wang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2013 - Elsevier
Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to
the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely …