purpose. To investigate the effect of IOP on retinal ganglion cell (RGC) apoptosis and
correlate the effects with IOP-induced changes in extracellular matrix (ECM) in the retina and …

purpose. To characterize a long-term elevated intraocular pressure (IOP) glaucoma model in
the rat with respect to electroretinographic (ERG) changes and the pattern and mechanism …

We developed and characterized a mouse model of elevated intraocular pressure (IOP) to
investigate the underlying cellular and genetic mechanisms of retinal ganglion cell (RGC) …

Glaucoma is a chronic and progressive optic nerve neuropathy involving the death of retinal
ganglion cells (RGCs). Elevated intraocular pressure (IOP) is considered to be the major risk …

Purpose. Diabetes mellitus (DM) is a risk factor for open-angle glaucoma, although the
mechanistic interrelationship of the two is debatable. The purpose of this study is to test …

purpose. To study the responses of glial cells to a short-term elevation in intraocular
pressure (IOP) in rats. methods. Adult Sprague-Dawley albino rats, 45 to 55 days old, were …

Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to
blindness. Over the past decade and a half, information has begun to emerge regarding …

purpose. The response of retinal ganglion cells (RGCs) to ocular pressure in glaucoma
likely involves signals from astrocytes and microglia. How glia-derived factors influence …

Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion
cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC …

This study investigated whether endoplasmic reticulum (ER) stress induced retinal ganglion
cell (RGC) death in chronic ocular hypertension, one of the RGC death mechanisms, using …