Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose
metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts …

Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol
accumulation during the hyperglycemia. The present article focuses on the role of phenol …

In this study, aldose reductase (AR) was purified from sheep kidney using chromatographic
methods and examined the interactions between some sulfonamides and the enzyme …

Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of
diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of …

Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts
glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic …

Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important
enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of …

Diabetic complications including nephropathy, neuropathy, and cataract are leading causes
of end-stage renal diseases and neurological disorders. Aldose reductase (AR), the rate …

Aldose reductase (AR) is an NADPH-dependent enzyme that catalyses the reduction of the
aldehyde to the corresponding alcohols. Diabetic complications including neuropathy …

Aldose reductase [ALR2; EC 1.1. 1.21], a key enzyme of polyol pathway, catalyzes NADPH-
dependent reduction of glucose to sorbitol (Sorbitol pathway), and an excessive …

Aldose reductase (AR), a cytosolic, monomeric oxidoreductase, is a key enzyme in the
polyol pathway which controls the conversion of glucose to sorbitol. The accumulation of …