The pathophysiology of sepsis is not completely understood. Bacteria are the main cause of
sepsis. Activated receptors of the innate immune system lead to an exaggerated immune …

Background: Sepsis, a systemic inflammatory response to infection, resulting in organ failure
and death. Pathogenic microbial agents trigger cascades of events in sepsis by stimulating …

Sepsis or septic shock is the fourth leading cause of long-stay intensive care admissions.
Death may occur despite antimicrobial therapy. The incidence of mortality from sepsis has …

Sepsis is defined as severe systemic inflammation in response to invading pathogens, or an
uncontrolled hyperinflammatory response, as mediated by the release of various …

Within the recent years preclinical and clinical investigations to a great extend increased the
pathophysiological understanding what is going on in patients with severe sepsis. It became …

Sepsis is a serious condition that is associated with high mortality despite advanced modern
medical treatment. Recent years have witnessed novel paradigms describing host …

The incidence of sepsis is increasing worldwide, yet the mortality rate has barely decreased
during the past decades and remains unacceptably high at between 20%-40%. New …

Sepsis results from the activation of a complex cascade of mediators, an appropriate and
necessary body response to infection or insult which can, however, become excessive and …

Sepsis, which is a highly heterogeneous syndrome, can result in death as a consequence of
a systemic inflammatory response syndrome. The activation and regulation of the immune …

Sepsis is a complex condition characterized by the simultaneous activation of inflammation
and coagulation in response to microbial insult. These events manifest as systemic …