The interphase nucleus is functionally organized in active and repressed territories defining
the transcriptional status of the cell. However, it remains poorly understood how the nuclear …

Chromatin is a critical regulator of neural plasticity, but basic principles of chromatin function
in neurons are unclear. In this issue of Neuron, Maze et al.(2015) establish histone H3. 3 …

Highlights•Epigenetic regulation represents a key mechanism of learning, memory and
cognition.•Chromatin topology is emerging as a major regulator of neuronal gene …

Highlights•New evidence shows that chromatin regulation is highly dynamic during memory
formation.•Chromatin is modified by incorporating functionally distinct histone variants to …

Highlights•Histone modifications are highly dynamic in the brain and drive changes in many
behaviors including learning and memory.•Chromatin-associated proteins that interact with …

Plasticity in gene expression is achieved by a complex array of molecular mechanisms by
which intracellular signaling pathways directly govern transcriptional regulation. In addition …

Recent advances in chromatin biology have identified a role for epigenetic mechanisms in
the regulation of neuronal gene expression changes, a necessary process for proper …

The interior of the neuronal cell nucleus is a highly organized three-dimensional (3D)
structure where regions of the genome that are linearly millions of bases apart establish sub …

This brief review focuses on the role of epigenetic mechanisms in plasticity and memory
formation, and their identification as targets of activity-dependent regulation in neurons …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …