Bacteria sense and respond to the environment, communicate, and continuously interact
with their surroundings, including host bodies. For more than a century, engineers have …

It was already clinically apparent 150 years ago that bacterial therapy could alleviate
diseases. Recently, a burgeoning number of researchers have been using bacterial …

Bacterial engineering modifies bacteria's genomic sequence using genetic engineering
tools. These engineered bacteria can produce modified proteins, peptides, nucleic acids …

Synthetic biology aims to apply engineering principles to biology by modulating the behavior
of living organisms. An emerging application of this field is the engineering of bacteria as a …

Highlights•Engineered bacteria provide a continuous supply of therapeutic
molecules.•Bacterial therapies target inflammation, immunity, cancer, and metabolic …

Bacteria have now been harnessed to combat human diseases, especially to meet the
challenge of antimicrobial resistance. Modulating the microbiome, particularly by genetically …

Our ability to generate bacterial strains with unique and increasingly complex functions has
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …

The use of bacterial cells as agents of medical therapy has a long history. Research that was
ignited over a century ago with the accidental infection of cancer patients has matured into a …

There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

A complex interplay of metabolic and immunological mechanisms underlies many diseases
that represent a substantial unmet medical need. There is an increasing appreciation of the …