Engineering microbial living therapeutics: the synthetic biology toolbox

DB Pedrolli, NV Ribeiro, PN Squizato… - Trends in …, 2019 - cell.com
Microbes can be engineered to act like living therapeutics designed to perform specific
actions in the human body. From fighting and preventing infections to eliminating tumors and …

Engineered live bacteria as disease detection and diagnosis tools

I Tanniche, B Behkam - Journal of Biological Engineering, 2023 - Springer
Sensitive and minimally invasive medical diagnostics are essential to the early detection of
diseases, monitoring their progression and response to treatment. Engineered bacteria as …

Bacterial therapies at the interface of synthetic biology and nanomedicine

J Hahn, S Ding, J Im, T Harimoto, KW Leong… - Nature Reviews …, 2024 - nature.com
Bacteria are emerging as living drugs to treat a broad range of disease indications.
However, the inherent advantages of these replicating and immunostimulatory therapies …

Bioengineered microbes in disease therapy

AW Paton, R Morona, JC Paton - Trends in molecular medicine, 2012 - cell.com
Naturally occurring microorganisms have been used therapeutically for over a century, but
the advent of modern techniques for genetic manipulation has created unprecedented …

[HTML][HTML] Engineered bacteria as drug delivery vehicles: principles and prospects

Y Zhou, Y Han - Engineering Microbiology, 2022 - Elsevier
The development of drug delivery vehicles is in significant demand in the context of
precision medicine. With the development of synthetic biology, the use of genetically …

Engineering live bacterial therapeutics to treat human diseases

IY Hwang - Current Opinion in Systems Biology, 2023 - Elsevier
In recent years, synthetic biology has provided many engineering approaches to reprogram
and engineer cells in diverse applications including the development of novel therapeutics …

Build-a-bug workshop: using microbial-host interactions and synthetic biology tools to create cancer therapies

V Raman, CP Deshpande, S Khanduja, LM Howell… - Cell Host & Microbe, 2023 - cell.com
Many systemically administered cancer therapies exhibit dose-limiting toxicities that reduce
their effectiveness. To increase efficacy, bacterial delivery platforms have been developed …

Engineering living bacteria for cancer therapy

L Rong, Q Lei, XZ Zhang - ACS Applied Bio Materials, 2020 - ACS Publications
Bacteria possess many unique properties in treating cancer that are unachievable with
standard methods, including specific tumor targeting, deep tissue penetration, and …

Engineered bacteria-based living materials for biotherapeutic applications

R Omer, MZ Mohsin, A Mohsin, BS Mushtaq… - … in Bioengineering and …, 2022 - frontiersin.org
Future advances in therapeutics demand the development of dynamic and intelligent living
materials. The past static monofunctional materials shall be unable to meet the requirements …

Synthetic engineered bacteria for cancer therapy

T Gong, J Wu - Expert Opinion on Drug Delivery, 2023 - Taylor & Francis
Introduction Cancer mortality worldwide highlights the urgency for advanced therapeutic
methods to fill the gaps in conventional cancer therapies. Bacteriotherapy is showing great …