Future advances in therapeutics demand the development of dynamic and intelligent living
materials. The past static monofunctional materials shall be unable to meet the requirements …

Highlights•Microbes are engineered to diagnose and treat many disorders and
diseases.•Biosensors improve the control of microbes engineered for medical …

The past decade has seen growing interest in bacterial engineering for therapeutically
relevant applications. While early efforts focused on repurposing genetically tractable model …

The discovery of antimicrobial drugs and their subsequent use has offered an effective
treatment option for bacterial infections, reducing morbidity and mortality over the past 60 …

Microbial products are essential for developing various therapeutic agents, including
antibiotics, anticancer drugs, vaccines, and therapeutic enzymes. Genetic engineering …

Genetically engineered bacteria have the potential to diagnose and treat a wide range of
diseases linked to the gastrointestinal tract, or gut. Such engineered microbes will be less …

The ability to modify existing microbiota at different sites presents enormous potential for
local or indirect management of various diseases. Because bacteria can be maintained for …

Synthetic biology builds programmed biological systems for a wide range of purposes such
as improving human health, remedying the environment, and boosting the production of …

The growing prevalence of antibiotic resistance calls for new approaches in the
development of antimicrobial therapeutics. Likewise, improved diagnostic measures are …

Highlights•Predictability and robustness are major challenges for synthetic
biology.•Engineering bacteria requires putting synthetic constructs into growing host …