The engineering of microbial cells to produce and secrete therapeutics directly in the human
body, known as advanced microbial therapeutics, is an exciting alternative to current drug …

Typically, the outcome of biologically engineered unit operations cannot be controlled a
priori due to the incorporation of ad hoc design into complex natural systems. To mitigate …

Highlights•Bacteria can act as engineered live therapeutics for tumor targeting.•New
strategies are needed to improve tumor colonization without causing widespread …

Background The emergence and prevalence of multidrug resistant (MDR) pathogenic
bacteria poses a serious threat to human and animal health globally. Nosocomial infections …

Antibiotic resistant bacterial infections are a global public health challenge that has been
increasing in severity and scope for the last few decades. Without creative solutions to this …

One of the primary limitations of cancer therapy is lack of selectivity of therapeutic agents to
tumor cells. Current efforts are focused on discovering and developing anticancer agents …

There is an increasing need for new cancer therapies. The antitumour effect of bacterial
infection has been well observed and practiced throughout history. Bacteria are well‐suited …

Recent advancements in cancer biology, microbiology, and bioengineering have spurred
the development of engineered live biotherapeutics for targeted cancer therapy. In …

The ability to recognize and react to specific environmental cues allows bacteria to localize
to environments favorable to their survival and growth. Synthetic biologists have begun to …

Engineered bacteria for therapeutic applications would benefit from control mechanisms that
confine the growth of the bacteria within specific tissues or regions in the body. Here we …