been linked with variation in body fat in some human studies, but, for leptin, causation has
been shown only in 2 obese children with homozygous missense mutations in the leptin …

Linkage of body mass index (BMI) to a broad region of chromosome 7q22-35 has been
reported in multiple studies. We previously published a multipoint LOD score of 4.9 at …

It has long been known that there is a genetic component to obesity, and that characterizing
this underlying factor would likely offer the possibility of better intervention in the future …

This chapter presents the current state of knowledge in the field of the genetics of human
obesity. The molecular approach has proved to be powerful in defining new syndromes …

The epidemic diffusion of obesity in industrialised countries has promoted research on the
aetiopathogenesis of this disorder. The purpose of this review is to focus mainly on the …

The heritability of obesity and body weight in general is high. A small number of confirmed
monogenic forms of obesity—the respective mutations are sufficient by themselves to cause …

It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …

Candidate gene and genome-wide association studies have led to the discovery of nine loci
involved in Mendelian forms of obesity and 58 loci contributing to polygenic obesity. These …

The heritability of obesity has long been appreciated and the genetics of obesity has been
the focus of intensive study for decades. Early studies elucidating genetic factors involved in …

Loos RJF, Bouchard C (Human Genomics Laboratory, Pennington Biomedical Research
Center, Baton Rouge, LA, USA). Obesity–is it a genetic disorder?(Review). J Intern Med …