Whether somatic mutations contribute functional diversity to brain cells is a long-standing
question. Single-neuron genomics enables direct measurement of somatic mutation rates in …

A major unanswered question in neuroscience is whether there exists genomic variability
between individual neurons of the brain, contributing to functional diversity or to an …

Somatic mutations occur during brain development and are increasingly implicated as a
cause of neurogenetic disease. However, the patterns in which somatic mutations distribute …

The healthy human brain is a mosaic of varied genomes. Long interspersed element-1
(LINE-1 or L1) retrotransposition is known to create mosaicism by inserting L1 sequences …

Neurons live for decades in a postmitotic state, their genomes susceptible to DNA damage.
Here we survey the landscape of somatic single-nucleotide variants (SNVs) in the human …

Somatic mutation in neurons is linked to neurologic disease and implicated in cell-type
diversification. However, the origin, extent, and patterns of genomic mutation in neurons …

Non-allelic recombination between homologous repetitive elements contributes to evolution
and human genetic disorders. Here, we combine short-and long-DNA read sequencing of …

Somatic copy number variations (CNVs) exist in the brain, but their genesis, prevalence,
forms, and biological impact remain unclear, even within experimentally tractable animal …

Accurate somatic mutation detection from single-cell DNA sequencing is challenging due to
amplification-related artifacts. To reduce this artifact burden, an improved amplification …

Background Post-zygotic mutations incurred during DNA replication, DNA repair, and other
cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of …