UV‐induced DNA damage can lead to melanoma, the most dangerous form of skin cancer.
Understanding the mechanisms employed by melanocytes to protect against UV is therefore …

Constitutive pigmentation determines the response to sun exposure and the risk for
melanoma, an oxidative stress–driven tumor. Using primary cultures of human melanocytes …

Melanocytes are producing melanin after UV irradiation as a defense mechanism. However,
UV-induced damage is involved in melanoma initiation, depending on skin phototype …

H2O2 and other reactive oxygen species are key regulators of many intracellular pathways.
Within mammalian skin, H2O2 is formed as a byproduct of melanin synthesis, and following …

Melanins have been associated with the development of melanoma and its resistance to
photodynamic therapy (PDT). Singlet molecular oxygen (1O2), which is produced by …

Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-
oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses …

Exposure of cultured human melanocytes to ultraviolet radiation (UV) results in DNA
damage. In melanoma, UV‐signature mutations resulting from unrepaired photoproducts are …

Melanin synthesis is an oxygen‐dependent process that acts as a potential source of
reactive oxygen species (ROS) inside pigment‐forming cells. The synthesis of the lighter …

The tyrosinase/oxygen enzymatic system catalyses the orthohydroxylation of l-tyrosine to l-
dopa and the oxidation of this to dopaquinone, which evolves non-enzymatically towards to …

Cultured human melanocytes derived from different skin types responded to frequent
treatment with ultraviolet (UV) light with increased melanin synthesis, decreased …