Multiple studies indicate that N-methyl-d-aspartate (NMDA) receptor hypofunction underlies
some of the deficits associated with schizophrenia. One approach for improving NMDA …

A subset of glutamate receptors that are specifically sensitive to the glutamate analog N-
methyl-D-aspartate (NMDA) are molecular coincidence detectors, necessary for activity …

A map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from
chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 …

Excitatory amino acids, like glutamate, may be involved in the symptomatology of
schizophrenia. This is suggested by the observations that various antagonists of the N …

Recently, a substantial amount of free d‐serine has been demonstrated in rat brain,
although it has long been presumed that d‐amino acids are uncommon in mammals. The …

Prefrontal cortex (Brodmann's area 9) levels of the methyl donor S-adenosyl methionine
were increased by about two-fold in schizophrenia and bipolar disorder patients, but not in …

Objective: The authors measured N-acetylaspartate (a putative neuronal marker), using in
vivo proton magnetic resonance spectroscopic imaging (1H-MRSI), in the frontal lobes of …

Hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has been implicated in the
pathophysiology of schizophrenia. The NMDAR contains a d-serine/glycine site on the NR1 …

d-Serine, an endogenous co-agonist of the N-methyl-d-aspartate (NMDA) receptor, plays an
important role in mammalian brain neurotransmission, via the NMDA receptor. d-Serine is …

OBJECTIVE: The purpose of this review is to integrate insights regarding novel
neurotransmitters or neuromodulators of neuropsychiatric significance. METHOD: Evolving …