Basal serum amino acids (including central monoamine precursors), central monoamines,
and hormones were studied in schizophrenic patients (drug-naive, n= 20; drug-withdrawn …

We review the role of two susceptibility genes; G72 and DAAO in glutamate
neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an …

A simple and versatile methodology using high-performance liquid chromatography (HPLC)
with fluorimetric detection was developed to simultaneously determine d-serine along with …

A simple and precise method for the simultaneous determination of free d-aspartic acid, d-
serine and d-alanine in mouse brain tissues was established, using a reversed-phase HPLC …

Schizophrenia is characterized by reduced hippocampal volume, decreased dendritic spine
density, altered neuroplasticity signaling pathways, and cognitive deficits associated with …

Recent evidence indicates that enhancing N-methyl-d-aspartate (NMDA) neurotransmission
with the treatment of NMDA/glycine site agonists, such as d-serine, or a glycine transporter-1 …

We have examined whether d-amino acid oxidase (DAO) regulates free d-serine content
using mutant ddY/DAO− mice lacking DAO activity. We find that the content of d-serine in the …

The 'NMDA hypofunction hypothesis of schizophrenia'can be tested in a number of ways.
DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the …

Recent studies have provided evidence for neuronal and oligodendrocyte-related
abnormalities being associated with schizophrenia. However, the functional interplay and …

Since d-amino acids were identified in mammals, d-serine has been one of the most
extensively studied “unnatural amino acids”. This brain-enriched transmitter-like molecule …