BACKGROUND: Glutamatergic dysregulation has been documented in schizophrenia but
has received less systematic study in affective illness. METHODS: Cerebrospinal fluid (CSF) …

There is substantial evidence, both pharmacological and genetic, that hypofunction of the N-
methyl-d-aspartate receptor (NMDAR) is a core pathophysiological feature of schizophrenia …

Previous research implicates altered metabolism of l-arginine, a versatile amino acid with a
number of bioactive metabolites, in the pathogenesis of schizophrenia. The present study …

Research suggests that dysfunctional glutamatergic signalling may contribute to depression,
a debilitating mood disorder affecting millions of individuals worldwide. Ketamine, a N …

Mammalian brain contains high levels of d-serine, an endogenous co-agonist of N-methyl d-
aspartate type of glutamate receptors. d-Serine is synthesized by serine racemase, a brain …

Abstract N-acetyl-aspartate (NAA) is a readily measured marker of neuronal metabolism.
Previous analyses in schizophrenia have shown NAA levels are low in frontal, temporal and …

The goal of this study was to evaluate the utility of using plasma levels of amino acids as an
indicator of the severity of depression. The samples were collected from 23 depressed …

Proton magnetic resonance spectroscopy (1 H-MRS) allows the non-invasive measurement
of several metabolites, including N-acetyl-aspartate (NAA), an amino acid exclusively …

Parkinson's disease, neuropathologically defined by the aggregation of α‐synuclein, is
characterized by neuropsychiatric symptoms such as depression and anxiety preceding the …

We investigated glutamate-related neuronal dysfunction in the anterior cingulate (AC) early
in schizophrenia before and after antipsychotic treatment. A total of 14 minimally treated …