Centenarians are the best example of successful ageing, since they have escaped the major
age-associated diseases, alzd most are in good mental and physical condition. Heye …

Recent observations indicate that immunosenescence is not accompanied by an
unavoidable and progressive deterioration of the immune function, but is rather the result of …

As is apparent from the many contributions to this Special Issue of the Journal, the impact of
age on immunity is nefarious, with all manner of dysregulated responses attributed to …

The immunology of aging literature has long been a body noted for its seeming
impenetrability and internal inconsistency. To some extent, this perception reflects the nature …

For over 10 years we have studied centenarians as a model to address the biological basis
of aging and longevity, with particular attention to immunology and genetics. The most …

Profound and complex changes in the immune response occur during the aging process.
Immunosenescence is reflected by a sum of disregulations of the immune system and its …

Abstract On April 7, 8, 2009 a Symposium entitled" Pathophysiology of Successful and
Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn …

Immunosenescence is a complex remodelling of the immune system which may contribute
significantly to morbidity and mortality in the elderly. Much evidence suggests an association …

Human immunosenescence contributes to morbidity and mortality in later life. The age-
associated increasing incidence ofcancer and cardiovascular disease plateaus at around 80 …

The practical consequences of ageing on the immune system are thought to be significant,
but data on the nature of altered functional immunological capacity and its clinical relevance …