Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort

RK Weersma, PCF Stokkers, AA van Bodegraven… - Gut, 2009 - gut.bmj.com
Background: Crohn's disease and ulcerative colitis have a complex genetic background. We
assessed the risk for both the development and severity of the disease by combining …

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort

RK Weersma, PCF Stokkers, I Cleynen… - Official journal of the …, 2009 - journals.lww.com
OBJECTIVES: Inflammatory bowel diseases (IBD)—Crohn's disease (CD) and ulcerative
colitis (UC)—are chronic gastrointestinal inflammatory disorders with a complex genetic …

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

DPB McGovern, A Gardet, L Törkvist, P Goyette… - Nature …, 2010 - nature.com
Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract
with a complex genetic and environmental etiology. In an effort to identify genetic variation …

Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility

BD Ye, DPB McGovern - Expert review of clinical immunology, 2016 - Taylor & Francis
Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory
bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations …

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies

M Boyd, M Thodberg, M Vitezic, J Bornholdt… - Nature …, 2018 - nature.com
Inflammatory bowel disease (IBD) is a chronic intestinal disorder, with two main types:
Crohn's disease (CD) and ulcerative colitis (UC), whose molecular pathology is not well …

Recent insights into the genetics of inflammatory bowel disease

JH Cho, SR Brant - Gastroenterology, 2011 - Elsevier
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1

JH Cho, DL Nicolae, LH Gold… - Proceedings of the …, 1998 - National Acad Sciences
The idiopathic inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis
(UC), are chronic, frequently disabling diseases of the intestines. Segregation analyses, twin …

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship

CA Anderson, DCO Massey, JC Barrett, NJ Prescott… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Identifying shared and disease-specific susceptibility loci for
Crohn's disease (CD) and ulcerative colitis (UC) would help define the biologic relationship …

[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

[PDF][PDF] Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP

A Zhernakova, EM Festen, L Franke, G Trynka… - The American Journal of …, 2008 - cell.com
The two main phenotypes of inflammatory bowel disease (IBD)—Crohn's disease (CD) and
ulcerative colitis (UC)—are chronic intestinal inflammatory disorders with a complex genetic …