Inflammatory bowel disease (IBD) has long been known to arise from the interplay between
host and environmental factors. From this, a picture is currently emerging in which IBD is …

The initial manifestations of ulcerative colitis, although unpleasant and discomforting, are not
necessarily alarming. Stomach cramps, diarrhoea and even rectal bleeding can arise from …

Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology.
As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide …

Genetic association studies have identified 215 risk loci for inflammatory bowel disease,,,,,,,,
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …

As discussed in articles elsewhere in this issue, irritable bowel syndrome (IBS) is a chronic
disorder characterized by abdominal pain or discomfort and diarrhea and/or constipation …

The FANTOM5 consortium utilised cap analysis of gene expression (CAGE) to provide an
unprecedented insight into transcriptional regulation in human cells and tissues. In the …

B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis
(UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n= 145; …

A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …

We present a genome-wide association study of ileal Crohn disease and two independent
replication studies that identify several new regions of association to Crohn disease …

Current sequencing-based analyses of faecal microbiota quantify microbial taxa and
metabolic pathways as fractions of the sample sequence library generated by each …