Nucleic acids can be programmed into enzyme-free catalytic DNA circuits (CDCs) to carry
out various functions ranging from DNA computing to signal amplifications for biosensing …

Isothermal, enzyme-free amplification methods based on DNA strand-displacement
reactions show great promise for applications in biosensing and disease diagnostics but …

Nucleic acid circuits have shown promising potential for amplified detection of biomarkers
with interest in biologically important engineering applications. In this work, by properly …

Nucleic acids are considered as perfect programmable materials for cascade signal
amplification and not merely as genetic information carriers. Among them, catalytic hairpin …

Catalyzed hairpin assembly (CHA) is a robust enzyme-free signal-amplification reaction that
has a wide range of potential applications, especially in biosensing. Although most studies …

As isothermal, enzyme-free signal amplification strategies, hybridization chain reaction
(HCR) and catalytic hairpin assembly (CHA) possess the advantages such as high …

Catalyzed hairpin assembly (CHA) is an important DNA engineering tool for a variety of
applications such as DNA nanotechnology and biosensing. Here we report a hairpin-type of …

Catalytic hairpin assembly (CHA) appears to be a particularly appealing nucleic acid circuit
because of its powerful amplification capability, simple protocols, and enzyme-free and …

Signal amplification is a key component of molecular detection. Enzyme-free signal
amplification is especially appealing for the development of low-cost, point-of-care …

Synthetic enzyme-free DNA nanomachine performs quasi-mechanical movements in
response to external intervention, suggesting the promise of constructing sensitive and …