'The definitive property of individuality at the organismal level lies in the effective
suppression of the differential propagation of subparts as a necessary strategy for …

Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical
level, but also at a tissue, organism, and population level. Multiple data streams, from …

Cancer is a complex disease, resulting from system-wide interactions of biological
processes rather than from any single underlying cause. The processes that drive all cancer …

Overview Cancers are complex, adaptive systems comprised of cancer cells that are
influenced by supporting cells, immune cells, as well as soluble and insoluble proteins that …

Since 10 years ago, when the seven hallmarks of cancer were first defined by Hanahan and
Weinberg, after decades of molecular, cellular and clinical investigations, new systems …

An important challenge facing the field is how better to translate in vitro discoveries to the
clinic. Computational systems biology approaches that use omic data to predict biology …

Cancer has been a paradigmatic example of a complex disease. It is the second leading
cause of death worldwide. Knowledge acquired on the mechanisms and potential causes …

Cancer research has focused on the identification of molecular differences between
cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules …

The unprecedented amount of data produced with high-throughput experimentation forces
biologists to employ mathematical representation and computation to glean meaningful …

Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …