Cancer Systems Biology is now accepted and recognized as a promising field both in
biological and clinical research. It relies on a rigorous formalization of regulation networks …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Abstract The AACR-NCI Conference “Systems Biology: Confronting the Complexity of
Cancer” took place from February 27 to March 2, 2011, in San Diego, CA. Several themes …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

Cancer is a complex and heterogeneous disease that exhibits high levels of robustness
against various therapeutic interventions. It is a constellation of diverse and evolving …

Cancer is a complex disease at many different levels. The molecular phenomenology of
cancer is also quite rich. The mutational and genomic origins of cancer and their …

Programmed cell death, together with proliferation and differentiation, is responsible for
maintaining the population of cells in all tissues. Dysregulation in this genetically-regulated …

The twenty-fi rst century has witnessed rapid advancement in computational technologies
that are increasingly being applied in cancer research. Thanks to availability of these high …

Cancer systems biology aims to understand cancer as an integrated system of genes,
proteins, networks, and interactions rather than an entity of isolated molecular and cellular …

Cancer is a highly complex disease that is often characterized by vast changes in the
genetic and epigenetic landscape. Those changes result in altered protein expression levels …