Systems biology uses systems of mathematical rules and formulas to study complex
biological phenomena. In cancer research there are three distinct threads in systems biology …

An overview of translational, human oncogenomics, transcriptomics and cancer interactomic
networks is presented together with basic concepts and potential, new applications to …

In order to understand how a cancer cell is functionally different from a normal cell it is
necessary to assess the complex network of pathways involving gene regulation, signaling …

Bioinformatics: Big data versus the big C | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Translational medicine has been leveraging new technologies and tools for data analysis to
promote the development of new treatments. Integration of translational medicine with …

The main conclusion is that systems biology approaches can indeed advance cancer
research, having already proved successful in a very wide variety of cancer‐related areas …

Over the past several decades an intense, primarily experimental, scientific effort has
yielded remarkable increases in our understanding of tumour biology. In 2003 alone over …

Current cancer therapies target a limited set of tumor features, rather than considering the
tumor as a whole. Systems biology aims to reveal therapeutic targets associated with a …

Abstract Systems biology takes an interdisciplinary approach to the systematic study of
complex interactions in biological systems. This approach seeks to decipher the emergent …

It is becoming evident that holistic perspectives toward cancer are crucial in deciphering the
overwhelming complexity of tumors. Single-layer analysis of genome-wide data has greatly …