For many years, there has been general interest in developing virtual cells or digital twin
models [1, 2]. This is due to (i) a purely curiosity-driven need to build theories of life and,(ii) …

The Human Genome Project has undoubtedly transformed our view on the practice of
cancer biology and has provided a huge impetus towards elucidation of new potential …

Cancer is identified by aberrations in cellular structure and cellular function. Gross
morphological changes are evident in both the cellular and nuclear membranes in tumor …

Molecular Biology research has seen significant advancements in experimental
technologies, frequently denoted as the'Omics' revolution. However, successful strategies for …

During the past decade, significant technological and computational advances have
provided unprecedented opportunities for gaining a better understanding of cancer biology …

Background: Frequently occurring in cancer are the aberrant alterations of regulatory onco-
metabolites, various oncogenes/epigenetic stochasticity, and suppressor genes, as well as …

Cancer is the leading cause of morbidity and mortality worldwide. Comprehensive
understanding of the evolution of molecular cell biology and cancer, and their crucial turning …

The biological processes that keep us healthy or cause disease, as well as the mechanisms
of action of possible drugs are inherently complex. In the face of this complexity, attempts at …

Cancer is a complex disease that involves multiple types of biological interactions across
diverse physical, temporal, and biological scales. This complexity presents substantial …

In this paper, we outline the status quo and approaches to further development of the
systems biology concepts with focus on applications in cancer prevention science. We …